The HilA Box and Sequences outside It Determine the Magnitude of HilA-Dependent Activation of PprgH from Salmonella Pathogenicity
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A comparative study on the colonization of Salmonella enteritidis hilA mutant and its parent strains in laying hens
BACKGROUND: Several regulatory proteins are involved in Salmonella invasion. The key regulator of SPI-1 (Salmonella pathogenicity island 1 ) is hilA, a transcriptional activator encoded on SPI-1 that regulates the expression of the SPI-1 secretion system. OBJECTIVES: Importance of hilA mutation on S. enteritidis colonization and shedding in layer hens was evaluated in a long-term experiment. ME...
متن کاملThe ATP-dependent lon protease of Salmonella enterica serovar Typhimurium regulates invasion and expression of genes carried on Salmonella pathogenicity island 1.
An early step in the pathogenesis of Salmonella enterica serovar Typhimurium infection is bacterial penetration of the intestinal epithelium. Penetration requires the expression of invasion genes found in Salmonella pathogenicity island 1 (SPI1). These genes are controlled in a complex manner by regulators in SPI1, including HilA and InvF, and those outside SPI1, such as two-component regulator...
متن کاملDetection of hilA gene sequences in serovars of Salmonella enterica subspecies enterica.
hilA gene promoter, component of the Salmonella Pathogenicity Island 1, has been found in Salmonella serovar Typhimurium, being important for the regulation of type III secretion apparatus genes. We detected hilA gene sequences in Salmonella serovars Typhi, Enteritidis, Choleraesuis, Paratyphi A and B, and Pullorum, by polymerase chain reaction (PCR) and hybridization techniques. The primers to...
متن کاملFur negatively regulates hns and is required for the expression of HilA and virulence in Salmonella enterica serovar Typhimurium.
Iron is an essential element for the survival of living cells. However, excess iron is toxic, and its uptake is exquisitely regulated by the ferric uptake regulator, Fur. In Salmonella, the Salmonella pathogenicity island 1 (SPI-1) encodes a type three secretion system, which is required for invasion of host epithelial cells in the small intestine. A major activator of SPI-1 is HilA, which is e...
متن کاملMolecular Identification of Salmonella Strains Isolated from Livestock in Alborz Province and Their Serotyping
Background and Objective: Salmonellosis is an important infectious zoonotic disease that makes it even more significant to identify and control the causative strains. Molecular methods, especially polymerase chain reaction (PCR), for virulence genes can help to quickly and accurately identify Salmonella strains. Accordingly, the purpose of this study was molecular identification based on sivH, ...
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تاریخ انتشار 2001